The Closed System Transfer Devices Market, valued at US$ 823M in 2021, is projected to grow at a 4.8% CAGR, reaching ~US$ 1140M by 2028. North America leads, driven by FDA regulations and increased oncology drug approvals. Asia-Pacific shows significant growth due to rising cancer cases and initiatives against hazardous drugs. Chronic disease prevalence, including cancer and diabetes, also fuels market demand.